白芍藥이 피부 미백 및 주름에 미치는 영향

Effects of Paeoniae radix alba(PRA) on Skin whitening and Elasticity using Melanoma cells

저자명 이종철, 박수연, 최정화, 김종한

문서유형 학술논문

참고문헌 43건

학술지 한방안이비인후피부과학회지 제25권 제1호 통권47호 (2012년 2월) pp.1-11 1738-6640 KCI 

발행정보 대한한방안이비인후피부과학회 |2012년 |한국 |한국어

초록

Objective : Paeoniae radix alba(PRA) can enrich the blood and regulate menstruation, astringe yin and arrest sweating, calm the liver and arrest pain. This study was designed to investigate effects of PRA on skin whitening and elasticity using melanoma cells. Methods : In this experiment, effect of PRA on cell viability, inhibition of melanin synthesis and inhibitory effect on tyrosinase and elastase. Results : 1. More than 1,000 ㎍/㎖ of PRA treated group showed lowered proliferation rates significantly compared to non-treated control group. 2. All of treated groups were lower levels of melanin synthesis respectively. 3. PRA did not show inhibitory effect on tyrosinase activities in vitro. But, PRA suppressed tyrosinase activities in B16F10 cells significantly. 4. PRA suppressed elastse type 1 activities in dose-dependent manner in vitro. But, PRA slightly suppressed elastase type 4 activities in vitro, and PRA also slightly suppressed elastase activities in vivo. Conclusion : These results suggest that PRA can inhibit melanin synthesis through ihhibitory action on tyrosinase activity and inhibt elastase activity, and also suggest that these results can be used for the study on maintaining skin whitening or elasticity.