알러지 유발 단백질이 제거된 수용성 로열젤리의 피부미백 효과

Whitening Efficacy of Water Soluble Royal Jelly Removed Allergenic Protein

저자명 한상미, 김정민, 김세건, 장혜리, 여주홍, 홍인표, 우순옥

문서유형 학술논문

참고문헌 28건

학술지 생약학회지 제45권 제3호 통권 178호 (2014년 9월) pp.262-267 0253-3073 KCI 

발행정보 한국생약학회 |2014년 |한국 |한국어

초록

Royal jelly composes of many components, especially protein. Protein is a major factor which cause allergy. We focused on water soluble royal jelly (WSRJ) that was removed allergy - inducing protein. 10-hyroxy-2-decenoic acid content of WSRJ is 2.42 g/100 g, which is double compared to that of lypophilized RJ. To further access WSRJ as a cosmetic ingredient and potential external treatment for topical use, we investigated its ability to inhibit tyrosinase activity and melanin biosynthesis on melanogenesis in B16F1 melanoma cells. We found that WSRJ increased the cell viability in B16F1 melanoma cell and WSRJ (1~10 mg/ml) inhibited melanin synthesis in with 10 nM α-melanocyte-stimulating hormone (α-MSH) for 48 h. WSRJ inhibited direct tyrosinase activity, which decreased melanin synthesis in α-MSH stimulated B16F1 melanoma cells. Thease findings suggest that WSRJ induces the down regulation of melanogenesis by inhibiting tyrosinase activation.